• BCsven@lemmy.ca
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    5 hours ago

    Well correlation studiear say 37% risk, but I recognize that correlation is not causation, however they have found the mechanism that causes the increased psychosis with genes.

    https://www.mdpi.com/2076-3417/12/20/10464

    AKT1 gene polymorphism rs2494732 as the main genetic factor

    C allele homozygosity significantly increases psychosis risk in cannabis users.

    Mechanism: Cannabis consumption slows AKT1 functionality, releasing greater dopamine in the striatum through indirect mechanisms.

    COMT and DAT1 gene interactions compound the risk

    CB-1 receptor activation leading to increased dopamine release and GABA inhibition