Glucagon-like peptide-1 agonism - GLP-1, common in obesity medicines - is not essential to weight management, according to preclinical research led by Richard DiMarchi and Matthias Tschöp, with funding from their startup company Bluewater Biosciences.
I lost 100 pounds, and I’m still dropping, without any drugs. My strategy:
Stop all soft drinks. Ice water, mostly, occasionally a Waterloo Peach, 0 calories/sugar. I will sometimes have a beer for dinner.
Eat whatever you want, but only when hungry, and only until not hungry. Serve small portions or half a sandwich. If you find yourself staring into the fridge, wondering what looks good, you aren’t hungry, you’re bored. Go do something else.
Distract yourself. My Dad quit smoking in the 80s with a Rubik’s Cube, picking it up whenever he had a craving. I did it with the guitar. Every time I had a craving, I picked up the guitar.
Just those three easy rules, and I lost 100+ pounds, and learned to play the guitar at the same time. You could lift weights, learn a language, write a book, go running, knit, or anything else.