In previous work, Safe and collaborators described NR4A1 as a “nutrient sensor” — a receptor that responds to compounds found in the diet and plays a role in maintaining health as the body ages.

“If you damage almost any tissue, NR4A1 responds to bring that damage down,” Safe said. “If you take that receptor away, the damage is worse.”

Research has shown that NR4A1 is involved in a wide range of biological processes, including inflammation, metabolism and tissue repair — all of which are closely tied to age-related diseases such as cancer, neurodegeneration and metabolic disorders.

NR4A1 also exacerbates cancer, supercharging it to the point NR4A1 inhibitors are often prescribed…

Like, that’s the problem with curing “aging”, when cells don’t die, that’s fucking cancer. Living 20 more years as Deadpool likely isn’t a great deal.

Even short term, this is encouraging cell division which burns thru telomere length faster than normal. So yeah, short term you’d feel “younger” but in five years you’ll look older than you would have due to things like loss if skin elasticity…

Of course, that would be from significant doses, not sure how much coffe until it’s a problem