How much is the speed drop from translation using Proton? Is it so big or just small? Hows the performance of cartoonish Windows only games? And whats your hardware and how much is the price? I’m sorry but I cannot test it myself because I’m still on my mobile. Can you also tell about how many games are compatible with Proton? What about non-popular games?
Apart from other things said here (e.g. AMD GPU), if you are planning on using wifi check that the adapter works well. Intel wifi usually works very well on Linux (although I have read that there are some issues with their newer wifi chips). AMD mobos usually use some kind of mediatek chipset. It might be better supported now, but I ended up replacing mine with another m.2 wifi (intel ax200).
A quick search for general support from the mobo vendor is probably a good idea too.