Also, can I unroll and let it do its thing on its frame or should it be on the floor?

Cant see how it would matter, but it would be preferable for me to get the frame setup and ready now and then deal with the mattress tomorrow if the plastic has to come off and I need the protector or if the plastic wont affect it decompressing then I can just do it all today and then take off plastic+do the protector tomorrow