Cisgender women have a naturally higher percentage of body fat than cisgender men, so lipophilic drugs have a larger volume of distribution in women. They sink into the fat tissue, stay in the body longer, and can take much more time to clear out. Overlooking sex-based variations in volume of distribution can be dangerous in an emergency situation, it absolutely can result in adverse drug reactions.
That kind of information can be a factor in an emergency medicine situation, it’s not worth pretending that it’s not the case.
Medicine is one of the areas where biological sex is actually relevant.
Cisgender women have a naturally higher percentage of body fat than cisgender men, so lipophilic drugs have a larger volume of distribution in women. They sink into the fat tissue, stay in the body longer, and can take much more time to clear out. Overlooking sex-based variations in volume of distribution can be dangerous in an emergency situation, it absolutely can result in adverse drug reactions.
That kind of information can be a factor in an emergency medicine situation, it’s not worth pretending that it’s not the case.
Medicine is one of the areas where biological sex is actually relevant.