As someone who’s been transitioning for 12+ years, I guarantee my body fat and hormones are literally nowhere near “genetic male”. Medically confirmed in fact, repeatedly. You’re making big assumptions about trans bodies that aren’t necessarily true.
I’d love to see what emergency meds you’re talking about that are more dependent on body fat composition rather than something like BMI, allergies, medical conditions, or age. But even then- soft tissues are the most affected by medical transition and are more closely aligned to their cis targets. That’s kinda the whole point. Not to mention the medical expertise behind whoever is administering said drugs.
Edit: oh you’re from lemmy.ml, that explains a lot
Cisgender women have a naturally higher percentage of body fat than cisgender men, so lipophilic drugs have a larger volume of distribution in women. They sink into the fat tissue, stay in the body longer, and can take much more time to clear out. Overlooking sex-based variations in volume of distribution can be dangerous in an emergency situation, it absolutely can result in adverse drug reactions.
That kind of information can be a factor in an emergency medicine situation, it’s not worth pretending that it’s not the case.
Medicine is one of the areas where biological sex is actually relevant.
As someone who’s been transitioning for 12+ years, I guarantee my body fat and hormones are literally nowhere near “genetic male”. Medically confirmed in fact, repeatedly. You’re making big assumptions about trans bodies that aren’t necessarily true.
I’d love to see what emergency meds you’re talking about that are more dependent on body fat composition rather than something like BMI, allergies, medical conditions, or age. But even then- soft tissues are the most affected by medical transition and are more closely aligned to their cis targets. That’s kinda the whole point. Not to mention the medical expertise behind whoever is administering said drugs.
Edit: oh you’re from lemmy.ml, that explains a lot
Cisgender women have a naturally higher percentage of body fat than cisgender men, so lipophilic drugs have a larger volume of distribution in women. They sink into the fat tissue, stay in the body longer, and can take much more time to clear out. Overlooking sex-based variations in volume of distribution can be dangerous in an emergency situation, it absolutely can result in adverse drug reactions.
That kind of information can be a factor in an emergency medicine situation, it’s not worth pretending that it’s not the case.
Medicine is one of the areas where biological sex is actually relevant.