• Maeve@kbin.earth
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    8 hours ago

    That’s still not statistically significant, and correlation does not imply causation. It serves as a caution, and I’m inclined to agree it’s not wise to risk it, but let’s be honest with ourselves and others.

    • BCsven@lemmy.ca
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      5 hours ago

      Well correlation studiear say 37% risk, but I recognize that correlation is not causation, however they have found the mechanism that causes the increased psychosis with genes.

      https://www.mdpi.com/2076-3417/12/20/10464

      AKT1 gene polymorphism rs2494732 as the main genetic factor

      C allele homozygosity significantly increases psychosis risk in cannabis users.

      Mechanism: Cannabis consumption slows AKT1 functionality, releasing greater dopamine in the striatum through indirect mechanisms.

      COMT and DAT1 gene interactions compound the risk

      CB-1 receptor activation leading to increased dopamine release and GABA inhibition