For me, it would be GLaDOS.
Portal 2 spoiler
She deleted the one remaining human part of herself because it was just too much to deal with. She releases you at the end of Portal 2 as a path of least resistance measure because “killing you is hard.”
What about you, what is your favorite media villain?
It’s actually why I listed the James Bond villain Elliot Carver from Tomorrow Never Dies because he was an analogue for Murdoch, a media magnate who wanted to control the world through disinformation. It was a prescient character, because that was still during 1997, long before FOX News had become the danger it actually is. Yet Carver is pretty on-the-nose for what actually ended up happening and we didn’t have a James Bond to save us.