• BCsven@lemmy.ca
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    7 hours ago

    I think the science paper I read was 7x higher rate on weed, ifyour had a certain gene. I will have to find it

    • Maeve@kbin.earth
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      7 hours ago

      That’s still not statistically significant, and correlation does not imply causation. It serves as a caution, and I’m inclined to agree it’s not wise to risk it, but let’s be honest with ourselves and others.

      • BCsven@lemmy.ca
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        4 hours ago

        Well correlation studiear say 37% risk, but I recognize that correlation is not causation, however they have found the mechanism that causes the increased psychosis with genes.

        https://www.mdpi.com/2076-3417/12/20/10464

        AKT1 gene polymorphism rs2494732 as the main genetic factor

        C allele homozygosity significantly increases psychosis risk in cannabis users.

        Mechanism: Cannabis consumption slows AKT1 functionality, releasing greater dopamine in the striatum through indirect mechanisms.

        COMT and DAT1 gene interactions compound the risk

        CB-1 receptor activation leading to increased dopamine release and GABA inhibition