Since so many other quotes are already claimed, how about some Outer Wilds:

Seriously, I tried everything I could think of […], and neither idea worked.

" " - Half-Life 2

Ah shit here we go again.

“Were it so easy.” - the Arbiter, Halo 3

“A toaster is just a death ray with a smaller power supply! As soon as I figure out how to tap into the main reactors, I will burn the world!” Toaster, Fallout New Vegas (Old World Blues)

“If you can hear the police knock on your door, the music isn’t loud enough” -Guitar Hero

“I used to be an adventurer like you, then I took an arrow in the knee”

“I don’t think I can forgive you for that.”

“…but I’d like to try.”

Everything that lives is designed to end. We are perpetually trapped… in a never-ending spiral of life and death. Is it a curse? Or some kind of punishment? I often think about the god who blessed us with this cryptic puzzle… and wonder if we’ll have the chance to kill him.

“It’s dangerous to go alone! Take this.” - The Legend of Zelda

Don’t have time to play with myself.

“Nah” -System Shock 2

Hello, my name is Dr. Glenn Pierce, and by now you may have realized that all of this has happened exactly the way it was supposed to. You see, everyone who comes to the institute does so because they feel they are no longer in control of something important to them. But, more often than not, the problem is not that the problems we face can’t be solved; the problem is that we become so afraid of failure that we refuse to see our problems from a new perspective – and so we do the same things again, and again, and again. And therein of course, we find exactly the failure we were looking for.

Your life will always be a struggle, and you will always have problems. But today, you had the chance to see things differently. Even though it meant facing obstacles that seemed impossible at first, you thought outside the box - and you overcame them. Because you saw things from every angle, you understood them for what they really were. Because you kept moving forward, no matter how far off the path you were told you were headed, or how unexpected it became…you found your way.

In a few minutes, you’ll be back in the real world, and some part of you will say that none of this was real: So how could it have meant anything? But – just like the power of perspective itself – it will have been as real as you believed it to be. All you’ve got to do is… wake… up.