• BCsven@lemmy.ca
      link
      fedilink
      arrow-up
      2
      ·
      11 hours ago

      I think the science paper I read was 7x higher rate on weed, ifyour had a certain gene. I will have to find it

      • Maeve@kbin.earth
        link
        fedilink
        arrow-up
        1
        ·
        10 hours ago

        That’s still not statistically significant, and correlation does not imply causation. It serves as a caution, and I’m inclined to agree it’s not wise to risk it, but let’s be honest with ourselves and others.

        • BCsven@lemmy.ca
          link
          fedilink
          arrow-up
          2
          ·
          8 hours ago

          Well correlation studiear say 37% risk, but I recognize that correlation is not causation, however they have found the mechanism that causes the increased psychosis with genes.

          https://www.mdpi.com/2076-3417/12/20/10464

          AKT1 gene polymorphism rs2494732 as the main genetic factor

          C allele homozygosity significantly increases psychosis risk in cannabis users.

          Mechanism: Cannabis consumption slows AKT1 functionality, releasing greater dopamine in the striatum through indirect mechanisms.

          COMT and DAT1 gene interactions compound the risk

          CB-1 receptor activation leading to increased dopamine release and GABA inhibition