• BCsven@lemmy.ca
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    8 hours ago

    Studies have shown a direct link to weed induced schizo disorders and those with genetic markers susceptible for it. Getting a DNA test is not on most peoples priority list.

      • BCsven@lemmy.ca
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        7 hours ago

        I think the science paper I read was 7x higher rate on weed, ifyour had a certain gene. I will have to find it

        • Maeve@kbin.earth
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          7 hours ago

          That’s still not statistically significant, and correlation does not imply causation. It serves as a caution, and I’m inclined to agree it’s not wise to risk it, but let’s be honest with ourselves and others.

          • BCsven@lemmy.ca
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            4 hours ago

            Well correlation studiear say 37% risk, but I recognize that correlation is not causation, however they have found the mechanism that causes the increased psychosis with genes.

            https://www.mdpi.com/2076-3417/12/20/10464

            AKT1 gene polymorphism rs2494732 as the main genetic factor

            C allele homozygosity significantly increases psychosis risk in cannabis users.

            Mechanism: Cannabis consumption slows AKT1 functionality, releasing greater dopamine in the striatum through indirect mechanisms.

            COMT and DAT1 gene interactions compound the risk

            CB-1 receptor activation leading to increased dopamine release and GABA inhibition